Fig. 4.

Schematic representation and 3D structure of mouse NPM2 with highlighted chromosomal protein interaction sites as determined by CXMS. The intensity of the interactions is depicted in red (see Supp. Table 1). (A) Schematic representation of the secondary structure organization of the NPM2 monomer. Acidic tracts are highlighted in black boxes. Note: Acidic tract A1 denotes the region where the A1 tract is seen in other species (but not in mouse) (see Fig.1). Beta barrels β1-β8 are also shown by wide arrows and intra-sheet hydrogen bonds are represented by dotted black lines. (B) Tertiary structure of the M.NPM2 monomer created using PyMOL. (C) Tertiary structure organization of the M.NPM2 pentamer created using PyMOL.