Fig. 4.

SDC4 are required for retaining the inherent β1 and β3 integrin expression pattern. A, α5, β1, and β3 integrin expressions were determined by Western-blot analysis. Forty-eight hours after transfection with indicated siRNA, A549 cells were exposed with or without TGF-β1 (5 ng/ml) for 48 h. GAPDH was used as loading control. B, Schema of simplified signal transduction pathways, regulating E-cadherin expression via SDC4, Snail and Slug, and consequent actin remodeling.