Fig 5. Shared and unique transcription factor binding site motifs in the vicinity of transcription start sites (TSSs) enriched in sample subgroups.

(A) The top 50 enriched motifs in each subgroup are shown. Embryo group contains early, middle, middle-late, and late subgroups. Primary cells group contains mesenchymal stem cells (MSCs), aortic smooth muscle cells (SMCs), and hepatocytes subgroups. Other tissues group contains leg and wing buds and extraembryonic subgroups. (B) Venn diagram showing overlaps of those top 50 motifs for embryo, primary cells, and other tissues against housekeeping groups. The number of shared motifs between groups is low, suggesting stage- or cell type–specific regulatory programs.