Table 4.
Comparison of Her-2 equivocal results by IHC and by D-FISH per the 2013 ASCO/CAP guidelines
| IHC (ASCO 2013) | Equivocal versus Others | ||||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| Negative (0&1+) | Equivocal( 2+) | Positive (3+) | Total | Mcnemar | Kappa | ||
| FISH (ASCO 2013) | Negative | 108(42.4) | 58(22.7) | 1(0.4) | 167(65.5) | P<0.001 | P=0.771 |
| Equivocal | 20(7.8) | 12(4.7) | 1(0.4) | 33(12.9) | |||
| Positive | 5(2.0) | 17(6.7) | 33(12.9) | 55(21.6) | |||
| Total | 133(52.2) | 87(34.1) | 35(13.7) | 255(100.0) | |||
Her-2 D-FISH: Her-2 dual-probe fluorescent in situ hybridization
IHC: Immunohistochemistry