Skip to main content
. Author manuscript; available in PMC: 2017 Sep 15.
Published in final edited form as: J Autoimmun. 2016 Apr 23;70:1–11. doi: 10.1016/j.jaut.2016.04.001

Figure 6. Topology of the GP neoepitopes within α5NC1 monomer (A) and within α345NC1 hexamer of GBM (B).

Figure 6

Molecular architecture of the EA-and EB-α5 epitopes is shown as representative example with specific arrangement of secondary structure elements including conservative disulfide (SS) bond and β-sheets (A). The hexamer is composed of two trimers, each consisting of α3NC1, α4NC1 and α5NC1 subunits (B). GP epitope regions EA and EB are located within α3NC1 and α5NC1 domains proximal to the collagenous domains.