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. Author manuscript; available in PMC: 2017 Sep 15.
Published in final edited form as: J Autoimmun. 2016 Apr 23;70:1–11. doi: 10.1016/j.jaut.2016.04.001

Figure 7. Structural analysis of GP epitopes.

Figure 7

To identify residues contributing to GP pathogenicity, the primary sequences of 15 residues homologous regions of six human chains were analyzed in terms of conservation, hydrophobicity, and isoelectric point (pI). Pathogenic EA regions of α3NC1 and α5NC1 were aligned and compared to the corresponding non-pathogenic α1, α2, α4, and α6NC1 sequences (left panels). The similar analysis was conducted for the EB regions (right panels). Residues involved in GP antibody recognition are marked with asterisks (*).