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. 2017 Sep 15;3(9):e1701735. doi: 10.1126/sciadv.1701735

Fig. 4. Demonstration of centrifugation for fractionating solubilized LNPs.

Fig. 4

(A) AFM images of LNPs in a diluted spent p-TsOH liquor of 10 wt % that is produced using Wiley-milled NE222 at P75T80t20. (B) AFM-measured topographical height profiles corresponding to lines 1 and 2 in (A). (C to E) AFM images of LNPs in the supernatant from the centrifuged sample in (A) at different speeds for 10 min, at 3000g (C), at 10,000g (D), and at 15,000g (E). (F) AFM-measured topographical height distributions of samples shown in (C) to (E).