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. Author manuscript; available in PMC: 2017 Sep 15.
Published in final edited form as: Sci Transl Med. 2017 Feb 22;9(378):eaah4680. doi: 10.1126/scitranslmed.aah4680

Fig. 2. S.aureus colonization correlates with a lack of antimicrobial activity in CoNS.

Fig. 2

(A) Schematic of a high-throughput antimicrobial screening of CoNS against S.aureus.(B) CFU of CoNS without (red) or with antimicrobial activity against S.aureus (green). Each bar represents data from individual subjects. (C) Frequency of CoNS colonies with activity against S.aureus. Data are reported for 29 healthy subjects and 41 nonlesional or 40 lesional sites from AD subjects. Subjects that had less than 25 CoNS colonies per swab were not included. Each point represents the frequency that anti–S.aureus activity was detected in all colonies isolated from each individual. Bar, mean. ****P < 0.0001. P values were calculated by two-tailed independent t test. (D) Correlation between proportion of CoNS strains that have the capacity to inhibit S.aureus growth and abundance of live S.aureus CFU on the skin surface. Each dot represents data from one individual. Quadrants are divided on the basis of the frequency of antimicrobial CoNS (>50 or <50%) and detection of live S.aureus (<1or >1CFU/cm2). The proportion (%) of subjects in each quadrant to total subjects is shown. L, lesional; NL, nonlesional.