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. Author manuscript; available in PMC: 2017 Sep 15.
Published in final edited form as: Sci Transl Med. 2017 Feb 22;9(378):eaah4680. doi: 10.1126/scitranslmed.aah4680

Fig. 7. Transplantation of antimicrobial CoNS reduces survival of S.aureus on human skin.

Fig. 7

(A) Characterization of CoNS clones used for autologous micro-biome transplant (AMT). Antimicrobial class of each clone was identified by whole-genome sequencing (refer to fig. S11 for more details). (B) Radial diffusion assay for anti–S.aureus activity secreted from each active CoNS strain used for AMT. Radial diffusion assay of bacteria and conditioned medium was conducted as described previously. (C) Effect of transplantation of antimicrobial CoNS or vehicle on the survival of S.aureus on the skin of five subjects with AD. S.aureus survival was measured by colony counting before transplant (pre) and 24 hours after a single application of bacteria (post). Application and analysis were done in a blinded fashion, and samples are from the contralateral arm of subjects treated with the identical vehicle containing antimicrobial bacteria or vehicle only. Data of AMT or placebo treatment (vehicle) are compared with data from four untreated control subjects with AD. P value was calculated by two-tailed paired t test.