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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Biochim Biophys Acta. 2017 Mar 29;1863(10 Pt A):2468–2476. doi: 10.1016/j.bbadis.2017.03.018

Figure 2.

Figure 2

hMC3R knockin mice. The murine Mc3r was replaced with the human consensus “wildtype” sequence (hWT) or the C17A + G241A human “double-mutant” (hDM) variant, which changes two amino acids in MC3R: Thr6Lys and Val81Ile (T6K+V81I). Mice homozygous for MC3R hDM have greater adiposity than mice homozygous for hWT.