Skip to main content
. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Biochim Biophys Acta. 2017 Apr 19;1863(10 Pt A):2486–2495. doi: 10.1016/j.bbadis.2017.04.010

Fig. 1. The central melanocortin system.

Fig. 1

POMC and AgRP neurons in the ARC are defined as “first order” neurons which integrate external stimuli and project to “second order” neurons with neural MCR expression. Neurons in PVN and IML mediate different physiological functions in energy homeostasis. MC3R and MC4R in POMC neurons can also serve auto-inhibitory and auto-excitatory roles to regulate energy homeostasis.