. Author manuscript; available in PMC: 2018 Oct 1.

Published in final edited form as: Biochim Biophys Acta. 2017 Apr 19;1863(10 Pt A):2486–2495. doi: 10.1016/j.bbadis.2017.04.010

Table 1. Biased ligands of neural MCRs.

Biased ligand	Receptor	Pathway	Cell system	Reference
AgRP	MC4R	Inhibiting Gs Activating Gi, Kir7.1, ERK1/2, and Akt	GT1-7 (Gi, Akt) PVH neurons (Kir7.1) HEK293T (ERK1/2)	[47, 50, 54, 56]
AgRP	MC3R	Inhibiting Gs Activating ERK1/2	HEK293T	[56]
MCL0020 ML00253764 Ipsen 5i	MC4R	Inhibiting Gs Activating ERK1/2	HEK293T	[50]
AP1189	MC3R	Not increasing Gs Activating ERK1/2 and calcium mobilization	HEK293A	[55]
THIQ NBI55886 NBI56453 NBI58702 NBI58704	MC4R	Activating Gs Impaired in calcium mobilization and receptor internalization	HEK293	[45]