Table 4.

Change over time in z-scored neuropsychological domains between groups defined after twelve months of antidepressant treatment

Domain	Difference in Slope	Standard Error	Test Statistic	p value
Episodic Memory			F2,1792 = 12.53 ES = 0.013	<0.0001
• Nonremitted Depressed - Nondepressed	−0.0275	0.0058	t = −4.76	<0.0001
• Remitted Depressed – Nondepressed	−0.0189	0.0060	t = −3.14	0.0017
• Nonremitted Depressed – Remitted Depressed	−0.0085	0.0067	t = −1.27	0.2030
Attention-Working Memory			F2,1590 = 15.25 ES = 0.018	<0.0001
• Nonremitted Depressed - Nondepressed	−0.0360	0.0074	t = −4.86	<0.0001
• Remitted Depressed – Nondepressed	−0.0315	0.0075	t = −4.19	0.0001
• Nonremitted Depressed – Remitted Depressed	−0.0045	0.0084	t = −0.53	0.5945
Verbal Fluency			F2,1816 = 4.15 ES = 0.005	0.0160
• Nonremitted Depressed - Nondepressed	−0.0066	0.0068	t = −0.97	0.3309
• Remitted Depressed – Nondepressed	−0.0206	0.0072	t = −2.88	0.0040
• Nonremitted Depressed – Remitted Depressed	0.0140	0.0079	t = 1.77	0.0770
Executive Function			F2,1748 = 6.34 ES = 0.010	0.0018
• Nonremitted Depressed - Nondepressed	−0.0231	0.0065	t = −3.54	0.0004
• Remitted Depressed – Nondepressed	−0.0056	0.0067	t = −0.82	0.4098
• Nonremitted Depressed – Remitted Depressed	−0.0175	0.0076	t = −2.31	0.0212

Reported data are statistical results of the interaction between diagnosis (remitted, nonremitted, or nondepressed) and study time, examining Z-transformed cognitive domain scores as the dependent variable. Models controlled for age, sex, race, education, and baseline domain score. Degrees of freedom for F statistics displayed as 2 (for the three groups), model error. T values determined from group comparisons within the models. ES = effect size