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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Photodiagnosis Photodyn Ther. 2017 Jun 21;19:140–152. doi: 10.1016/j.pdpdt.2017.06.010

Figure 2. Use of exogenous ALA to bypass regulation of heme biosynthetic cycle to produce excess PPIX that acts as a potent PS within mitochondria.

Figure 2

ALA-S = 5-aminolevulinic acid synthase

ALA-D = 5-aminolevulinic acid dehydratase

PBG-D = porphobilinogen deaminase

UCS = uroporphyrinogen co-synthase

UGD = uroporphyrinogen decarboxylase

CPO = coproporphyrinogen oxidase

PPO = protoporphyrinogen oxidase

FCH = ferrochelatase