Table 1.
Characteristics of study participants by quintile of high sensitivity troponin I levels at day of intubation (day 0, baseline).
| Characteristic | Overall | Quintile of HS-troponin (range, ng/L) | P value | ||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| First (1.3 – 7.2) | Second (7.2 – 20.9) | Third (20.9 – 71.9) | Fourth (71.9 – 296.5) | Fifth (>296.5) | |||
| Number | 1,057 | 211 | 211 | 212 | 211 | 212 | |
| HS-troponin, ng/L | 1073.5 | 3.3 | 13.1 | 41.3 | 152.7 | 5142.6 | |
| Age, years | 50.4 | 46.6 | 51.4 | 51.3 | 51.0 | 51.6 | <0.001 |
| Ethnicity, % | 0.01 | ||||||
| White | 68.9 | 74.4 | 69.7 | 66.5 | 74.4 | 59.4 | |
| Black | 18.8 | 11.9 | 19.0 | 20.8 | 17.5 | 25.0 | |
| Other | 12.3 | 13.7 | 11.4 | 12.7 | 8.1 | 15.6 | |
| Male sex, % | 51.9 | 53.6 | 48.8 | 52.8 | 47.9 | 56.6 | 0.36 |
| Primary cause of ARDS, % | 0.001 | ||||||
| Aspiration | 16.0 | 14.2 | 15.6 | 20.3 | 12.3 | 17.0 | |
| Pneumonia | 47.8 | 56.4 | 55.0 | 44.3 | 45.5 | 38.2 | |
| Sepsis | 22.2 | 15.2 | 17.1 | 25.0 | 22.8 | 31.1 | |
| Transfusion | 1.8 | 1.4 | 1.4 | 0.0 | 3.3 | 2.8 | |
| Trauma | 4.2 | 1.9 | 2.4 | 4.2 | 8.1 | 4.2 | |
| Other | 8.0 | 10.9 | 8.5 | 6.1 | 8.1 | 6.6 | |
| Temperature, °C | 37.5 | 37.3 | 37.6 | 37.6 | 37.6 | 37.7 | 0.002 |
| Heart rate, beats per min | 102.0 | 96.8 | 100.6 | 102.0 | 102.7 | 107.8 | <0.001 |
| Systolic BP, mmHg | 112.6 | 113.4 | 114.1 | 113.6 | 111.6 | 110.2 | 0.28 |
| Diastolic BP, mmHg | 59.0 | 58.5 | 58.4 | 60.0 | 59.2 | 58.8 | 0.66 |
| Vasopressor use, % | 32.2 | 19.4 | 28.0 | 34.4 | 35.0 | 44.3 | <0.001 |
| Height, cm | 169.5 | 168.7 | 169.1 | 169.8 | 169.8 | 170.3 | 0.59 |
| Weight, kg | 79.9 | 78.9 | 78.9 | 81.6 | 80.2 | 79.3 | 0.68 |
| SOFA score | 7.7 | 6.6 | 7.3 | 7.7 | 7.9 | 8.4 | <0.001 |
| Tidal volume, mL | 477.5 | 466.2 | 480.0 | 474.0 | 473.0 | 491.4 | 0.21 |
| PEEP, cm H2O | 9.47 | 9.16 | 9.16 | 9.52 | 9.78 | 9.67 | 0.37 |
| Plateau pressure, cm H2O | 26.2 | 25.5 | 26.9 | 25.9 | 25.9 | 26.7 | 0.28 |
| FiO2, | 0.65 | 0.64 | 0.66 | 0.65 | 0.65 | 0.67 | 0.64 |
| PaO2/FiO2 ratio, | 149.0 | 151.3 | 146.5 | 142.8 | 152.3 | 155.3 | 0.37 |
| Lung compliance, mL/cmH2 | 31.0 | 32.8 | 30.6 | 34.1 | 33.8 | 31.9 | 0.33 |
| Murray Lung Injury score | 2.87 | 2.90 | 2.98 | 2.78 | 2.79 | 2.84 | 0.11 |
| pH | 7.36 | 7.39 | 7.36 | 7.36 | 7.36 | 7.35 | 0.003 |
| pCO2, mmHg | 39.6 | 40.9 | 40.6 | 39.0 | 39.2 | 38.3 | 0.04 |
| pO2, mmHg | 90.3 | 91.0 | 86.9 | 86.2 | 90.1 | 96.0 | 0.13 |
| Creatinine, mg/dL | 1.52 | 1.08 | 1.46 | 1.54 | 1.54 | 1.97 | <0.001 |
Values in the Table were calculated using multiple imputation to take missing data into account (see Supplemental Table 1 for description of data available for each variable).