Table 3.
Hazard ratios for 60-day mortality by quintile of high sensitivity troponin I levels at day of intubation (day 0, baseline).
| Model | Quintile of HS-troponin (range, ng/L) | 90th vs. 10th percentile | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| First (1.3 – 7.2) | Second (7.2 – 20.9) | Third (20.9 – 71.9) | Fourth (71.9 – 296.5) | Fifth (>296.5) | ||
| Number of participants | 211 | 211 | 212 | 211 | 212 | |
| Mean HS-troponin | 3.3 | 13.1 | 41.3 | 152.7 | 5142.6 | |
| Number of deaths (%) | 47 (22.2) | 55 (26.1) | 56 (26.4) | 60 (28.4) | 74 (34.9) | |
| Model 1 | ||||||
| Hazard ratio | 1.00 | 1.07 | 1.12 | 1.24 | 1.60 | 1.57 |
| (95% confidence interval) | (reference) | (0.73 – 1.60) | (0.76 – 1.65) | (0.85 – 1.83) | (1.11 – 2.32) | (1.17 – 2.11) |
| P-trend | 0.003 | |||||
| Model 2 | ||||||
| Hazard ratio | 1.00 | 1.00 | 0.95 | 0.99 | 1.18 | 1.21 |
| (95% confidence interval) | (reference) | (0.67 – 1.49) | (0.64 – 1.40) | (0.66 – 1.46) | (0.81 – 1.73) | (0.88 – 1.65) |
| P-trend | 0.24 | |||||
| Model 3 | ||||||
| Hazard ratio | 1.00 | 0.92 | 0.80 | 0.88 | 0.94 | 1.01 |
| (95% confidence interval) | (reference) | (0.62 – 1.37) | (0.53 – 1.19) | (0.59 – 1.30) | (0.64 – 1.39) | (0.73 - 1.39) |
| P-trend | 0.94 | |||||
Values in the Table were calculated using multiple imputation to take missing data into account (see Supplemental Table 1 for description of data available for each variable).
Model 1: Adjusted for age, sex, and randomized trial assignment.
Model 2: Further adjusted for SOFA score.
Model 3: Further adjusted for use of vasopressors and heart rate.