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Structures of classical melanocortin ligands. (A) POMC-derived naturally occurring agonists (the common His-Phe-Arg-Trp tetrapeptide is highlighted in red). (B) Sequences of the endogenous antagonists AGRP and ASP (the active Arg-Phe-Phe tripeptide is highlighted in blue). (C) NDP-MSH, MTII and SHU9119 (hypothesized pharmacophore region highlighted in red).
