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Small-molecule melanocortin scaffolds derived from the Merck compound THIQ. Scaffolds are grouped by company disclosing the structures: Merck (green), Neurocrine Biosciences, Inc. (red), or Pfizer (blue). In the center, THIQ, MB243, and MK0493 are select Merck compounds disclosed before 2007, the His-DPhe-Arg-Trp hypothesized melanocortin pharmacophore, and an illustrative spiroinanyl piperidine core structure.
