. Author manuscript; available in PMC: 2018 Oct 1.

Published in final edited form as: Biochim Biophys Acta. 2017 Mar 29;1863(10 Pt A):2414–2435. doi: 10.1016/j.bbadis.2017.03.020

Table 2.

Table of selective melanocortin agonists for the mouse MCRs. Selectivity was defined to be at least 100-fold more potent between at least two receptor subtypes. Ligands are grouped by receptor selectivity. In some publications, numerous ligands were reported with the same selectivity profiles. In these instances, only the most potent ligands were chosen.

Selective For:	First Author	Year	Ref	Compound ID	Compound EC₅₀ (nM)

					mMC1R	mMC3R	mMC4R	mMC5R
mMC1R	Todorovic, Aleksandar	2007	[124]	10	*5.9*	>100000	41	30
	Todorovic, Aleksandar	2007	[124]	11	14	>100000	>100000	25
	Todorovic, Aleksandar	2007	[124]	12	*5.1*	10% @ 100μM	63% @ 100μM	19
	Singh, Anamika	2014	[125]	AMW6103	*0.81*	5300	440	31
	Singh, Anamika	2013	[126]	4	*1.9*	4500	290	415

mMC3R	Todorovic, Aleksandar	2016	[47]	[Ala⁴]α-MSH	12000	17	120	60

mMC4R	Todorovic, Aleksandar	2007	[124]	10	5.9	>100000	41	30
	Hess, Shmuel	2008	[129]	4	28	1300	4	2
	Proneth, Bettina	2008	[130]	11	280	240	*2.8*	2.9

mMC5R	Todorovic, Aleksandar	2007	[124]	10	5.9	>100000	41	30
mMC5R	Hess, Shmuel	2008	[129]	4	28	1300	4	2