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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: J Mol Cell Cardiol. 2017 Jul 25;111:69–80. doi: 10.1016/j.yjmcc.2017.07.010

Figure 1. Sequence alignment of the Cx45CT dimerization domain (A333-N361) from different species.

Figure 1

Sequence alignment of the A333-N361 region using Clustal Omega to all available Cx45 RefSeq sequences revealed a high degree of conservation within this region, with 72.4% identical, 20.6% conserved, and 6.9% non-conserved residues. For clarity, the sites of point mutations in the Cx45 6E construct are indicated by the single letter code above the alignments. Degree of site conservation (excluding Cx45 6E mutations) is indicated at the bottom, * = identical, : and . = high conservation and intermediate conservation, respectively.