Figure 1.
The canonical HDAC substrate peptidyl acetyl-L-lysine and structurally-related cyclic tetrapeptide inhibitors. The ketone carbonyl group of each inhibitor is isosteric with the scissile carbonyl of acetyl-L-lysine.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.