Table 1. Age-specific and overall relative reproductive success of men with mitochondrial disease.

Disease burden	No. patients	Age low	Age high	Births	Person-years	GFR pop	Ratio	Ratio L	Ratio U	P value
All patients
		15	19	4	470	0.0108	0.7860	0.2142	2.0125	0.8500
		20	24	17	468	0.0631	0.5755	0.3353	0.9215	0.0180
		25	29	22	452	0.0996	0.4885	0.3062	0.7396	2.22E−04
		30	34	36	403	0.0950	0.9402	0.6585	1.3017	0.7918
		35	39	13	368	0.0608	0.5806	0.3092	0.9929	0.0464
		40	44	5	325	0.0267	0.5755	0.1869	1.3431	0.2720
		45	49	0	269	0.0091	0.0000	0.0000	1.5011	0.1713
		50	54	0	167	0.0024	0.0000	0.0000	9.2989	1
		55	59	0	110	0.0010	0.0000	0.0000	33.1035	1
		60	64	0	79	0.0005	0.0000	0.0000	97.5063	1
				97	3111	0.0480	0.6495	0.5267	0.7923	6.2 × 10−06
By disease burden
Low	27			32	923	0.046	0.7544	0.516	1.065	0.1183
Medium	27			29	978	0.0478	0.6203	0.4155	0.8909	0.0073
High	28			23	712	0.0528	0.6118	0.3878	0.918	0.0146
By genotype
mtDNA	73			76	2364	0.0489	0.6569	0.5176	0.8222	0.0001
nDNA	21			21	747	0.0450	0.6252	0.3870	0.9557	0.0275

Abbreviations: GFR, general fertility rate; mtDNA, mitochondrial DNA; nDNA, nuclear DNA.