. Author manuscript; available in PMC: 2018 Sep 15.

Published in final edited form as: Clin Cancer Res. 2017 May 24;23(18):5469–5479. doi: 10.1158/1078-0432.CCR-16-3277

Table 1. The parameters used for the model simulation for lung cancer.

Parameters	Values
Growth fraction (GF)	0.25 (40)
Tumor doubling time (T_D)	100 days (39)
Cell cycle time (T_C)	2 days (37)
Fraction of cells in P-compartment (f ^P)	50^a %
G1-phase in P (f ^P_G1)	28 % (41)
S-phase in P (f ^P_S)	12 % (41)
G2/M-phase in P (f ^P_G2/M)	10 % (41)
Fraction of cell in I-compartment (f ^I)	27^a %
Fraction of cell in H-compartment (f ^H)	23^a %
Ratio of alpha of G1- to S-phase (α_G1/α_S)	2^b
Ratio of alpha of G2/M- to S-phase (α_G2/M/α_S)	3^b
Reference radiosensitivity at 2Gy/fx (α_ref)	0.35^c Gy^-1
Alpha-beta ratio (α/β)	10^c Gy
OER of I-compartment at 2 Gy/fx (OER_I,ref)	2^c
OER of H-compartment at 2 Gy/fx (OER_H,ref)	1.37 (43)

Estimated from GF and TD in the model

Assumed parameters based on radiosensitivity analysis of synchronized cell population (32,33)

Initially assumed values; various values of these parameters were tested in the sensitivity test