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. Author manuscript; available in PMC: 2018 Aug 15.
Published in final edited form as: Neuroimage. 2017 Jun 7;157:341–350. doi: 10.1016/j.neuroimage.2017.06.007

Fig. 7. In vivo Z-spectra and MTRasym-spectra from rat brain with MCAO.

Fig. 7

Z-spectra with a saturation power of 34 Hz were obtained from rat brains with ischemic region (n = 4). The ipsilateral (solid contour) and contralateral (dashed contour) ROIs were selected based on the ADC map (Inset). (A) Z-spectra obtained from two ROIs are similar for most of the frequency range, except small changes at the amide and guanidyl frequencies. (B) The MTRasym-spectra showed that the ipsilateral ischemic region has reduced amide-CEST and enhanced guanidyl-CEST signals. Note that other signals in the Z-spectra are insensitive to ischemia, such as from aliphatic protons or the MTC effect.