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. Author manuscript; available in PMC: 2017 Sep 17.
Published in final edited form as: Mol Pharm. 2017 Jul 19;14(8):2831–2842. doi: 10.1021/acs.molpharmaceut.7b00343

Table 3.

Summary of Chelator Number and Radiolabeling Yield Obtained with 89Zr for Each Immunoconjugatea

DFO-NCS–trastuzumab 4a– trastuzumab 4b– trastuzumab 8– trastuzumab
av no. of chelators 1.03 0.54 0.81 0.45
radiolabeling yield (90 min, 25 °C) 95 ± 2% 92 ± 3% 63 ± 5% 16 ± 2%
a

Determined using radiometric isotope dilution assay.