Figure 1.

Germinal Center reaction as a birth-death-mutation process. (A) Schematics representation of the agent based model. Each cell has a birth rate (λ), a death rate (μ). Upon division the BCR affinity changes according to Equation (9) with a constant D. (B) Example of a single simulation. The free growth phase lasts for 6 days, followed by a competitive phase lasting 16 days. Each colored curve represents a different clone. The parameters used in the simulation are detailed in Table 1 but with D = 0.01.