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. 2017 Sep 15;7:11717. doi: 10.1038/s41598-017-10343-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genetic mapping and identification of the seal mutation. (A) The seal mutation was mapped to chromosome 11 on 34 meioses with peak LOD score of 6.9. Phenotypic classification was based on the inducible defect in hind limb movement. (B) Fine mapping of the mutation on chromosome 11 using microsatellite markers. The seal mutation was confined to a critical region marked by D11mit289 and D11mit67 with five crossover events proximal and three crossovers distal to the mutation. (C) DNA sequence chromatograms of the region containing the seal mutation. (D) Illustration of the position of the seal mutation relative to exons 36 and 37 of Col1a1.