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. 2017 Sep 15;7:11717. doi: 10.1038/s41598-017-10343-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Reduced type I collagen gene expression in seal mice. Col1a1 gene expression relative to Gapdh in the femur were measured by quantitative RT-PCR using primer sets targeting sequences in exons 36 and 37, or exons 40 and 41. The ratio of Col1a1 exon 36–37/40–41 was analyzed for total RNA (A), nuclear RNA (B), and cytoplasmic RNA (C). P-values, (A) P = 0.007, P = 0.002, and n.s. from left, (B) P = 0.036, P = 0.040, and n.s. from left, and (C) P = 0.002, P = 0.027, and n.s. from left. N = 3 mice per genotype. Data are expressed as mean ± SEM.