Table 2.
Biomarker Levels by HIV Serostatusa
| Biomarker | HIV+ (N = 329) | HIV− (N = 197) | P Value |
|---|---|---|---|
| sCD14 (ng/mL), median (IQR) | 1597 (1389–1841) | 1294 (1135–1471) | <.001 |
| sCD163 (ng/mL), median (IQR) | 642 (486–822) | 535 (447–674) | <.001 |
| Adiponectin (ng/mL), median (IQR) | 6167 (3955–9896) | 7038 (4916–9539) | .16 |
| CRP (µg/mL), median (IQR) | 1.3 (0.7–2.9) | 1.1 (0.6–2.1) | .03 |
| Cystatin C (mg/L), median (IQR) | 0.8 (0.8–1.0) | 0.8 (0.7–0.9) | <.001 |
| D-dimer (µg/mL), median (IQR) | 0.2 (0.1–0.3) | 0.2 (0.1–0.3) | .14 |
| Fibrinogen (mL/dL), median (IQR) | 327 (279–376) | 332 (301–377) | .06 |
| ICAM-1 (ng/mL), median (IQR) | 251 (214–298) | 224 (197–268) | <.001 |
| IL-6 (pg/mL), median (IQR) | 1.4 (1.0–2.2) | 1.3 (0.9–2.0) | .11 |
| IL-18 (pg/mL), median (IQR) | 309 (211–448) | 227 (163–354) | <.001 |
| Leptin (pg/mL), median (IQR) | 5208 (2260–9828) | 6384 (3547–11 320) | .01 |
| MCP1 (pg/mL), median (IQR) | 268 (208–350) | 234 (184–299) | <.001 |
| Osteoprotegerin (pmol/L), median (IQR) | 4.6 (3.9–5.6) | 4.4 (3.6–5.2) | .02 |
| RANKL (pg/mL), median (IQR) | 8 (2–21) | 14 (8–28) | <.001 |
| TNFαR1 (pg/mL), median (IQR) | 1137 (964–1425) | 1156 (979–1377) | .89 |
| TNFαR2 (pg/mL), median (IQR) | 6343 (5346–7628) | 5834 (5077–6852) | .002 |
Abbreviations: CRP, C-reactive protein; HIV, human immunodeficiency virus; ICAM, intercellular adhesion molecule; IL, interleukin; IQR, interquartile range; MCP, monocyte chemoattractant protein; RANKL, receptor activator of nuclear factor κB ligand; s, soluble; TNFαR, tumor necrosis factor α receptor.
aBold signifies statistical significance (P < .05).