Figure 1. Obatoclax potently inhibits the clonogenic potential of oral cancer cells.

(A) Basal level expression of important pro and antiapoptotic BCL-2 family proteins in human oral cancer cells. β-actin served as loading control. (B) Chemical structure of Obatoclax. (C) Sensitivity of the four cell lines to Obatoclax was determined by the clonogenic assays. The survival (colony forming units) is expressed as percentage of vehicle controls. Data is represented as mean ± SEM of three independent experiments. (D) Effect of Obatoclax treatment on MCL-1 expression in the four OSCC cell lines. Images shown are representatives of triplicate experiments.