Figure 11.

(A) In vivo efficacy of Obatoclax. BALB/C Nude mice bearing subcutaneous tumors derived from SCC029B cell line were administered a cumulative dose of the drug as indicated distributed evenly over a period of five consecutive days. Tumor volumes were measured for a period of 15–20 days post drug administration. The data is expressed as mean + SEM of the mean tumour volumes for each group (six animals per group). (B) Ionizing radiation treatment exhibits synergism when combined with Obatoclax. A combination of Obatoclax and ionizing radiation (IR) significantly (p < 0.05) inhibited the clonogenic potential of OSCC cells as compared to the either treatments alone.