Table 1. Patients analyzed: Total=940 probands, with a mutation=179, BRCA1=105 and BRCA2=74.

Group	n	Patients with a mutation / Nv (n)	Tumor/s in patients with a mutation (n)
Diagnosed ≤ 40 years Healthy ≤ 40 years	198 135	BRCA1: 41 / 4 BRCA2: 18 / 6 BRCA1: 5 BRCA2: 4 / 1	Br(33)/b-Br(5)/Br & Ov(2)/Ov(4)/b-Br & Ov(1) Br(20)/b-Br(2)/Br & Ov(1)/Ov(1) ----- -----
Diagnosed > 40 years Healthy > 40 years	498 95	BRCA1: 45 / 3 BRCA2: 31 / 5 BRCA1: 5 / 1 BRCA2: 4 / 1	Br(33)/b-Br(2)/Br & Ov(3)/Ov(7)/b-Ov(1)/b-Br & Ov(2) Br(29)/b-Br(1)/Br & Ov(4)/b-Br & Ov(1)/b-Ov(1) ----- -----
Men diagnosed ≤ 40 years Men diagnosed > 40 years Men Healthy > 40 years	1 12 1	BRCA1: 1 BRCA2: 0 BRCA1: 0 BRCA2: 3 BRCA1: 0 BRCA2: 0 /1	Br & pancreas (1) ----- ----- Br(2)/b-Br(1) ----- -----
Total	940	BRCA1: 97 / 8 BRCA2: 60 / 14	----- -----

n: number of probands. Nv: novel mutation. Br:breast; Ov: ovary; b-: bilateral