Figure 2. LncRNAs expressed in B-cell differentiation or pathology.

B-cell differentiation in BM and lymphoid tissue with distinct types of B-cell malignancies originating from cells blocked at different stages of maturation. B-ALL cells resemble Pro/Pre-B lymphocytes; CLL originate from naïve or activated unmutated IGHV B-cells in the marginal zone or from mutated IGHV committed memory B-cell; MCL are like B-cells from the mantle zone; BL resemble dark zone B-cells; FL and GC-DLBCL originate from light zone B-cells; ABC-DLBCL show characteristic of late GC B-cells; MM and PCL originate from mature PCs. Differentially expressed lncRNAs are reported for each stage of B-cell maturation, and for distinct B-cell malignancies as compared to normal B-cell.