Table 1. LncRNAs with roles in normal B-cells.
lncRNA(s)/alias | Stage of B-cell | Genome location | Function | Molecular mechanism | Reference(s) |
---|---|---|---|---|---|
MYB-AS1, SMAD1-AS1, LEF1-AS1 | pre-B1 and pre-B2 cells | 6q23.3, 4q31.21, 4q25 | Involvement in early B-cell development | Antisense transcripts to TFs with well-known roles in early B-cells | [23] |
CRNDE | pre-B1, pre-B2, CBs and, to a lesser extent, CCs | 16q12.2 | Involvement in mitotic cell cycle related processes | Promotion of the metabolic changes by which cancer cells switch to aerobic glycolysis | [23, 25–27] |
RP11-132N15.3/lnc-BCL6-3 | CBs and, to a lesser extent, CCs | 3q27.3 | Involvement in the modulation of the GC reaction | LincRNA possibly regulating the transcriptional repressor BCL-6 | [23] |
Abbreviations: CC, centrocyte; CB, centroblast; GC, germinal center