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. 2017 Apr 20;8(36):60605–60623. doi: 10.18632/oncotarget.17303

Table 1. LncRNAs with roles in normal B-cells.

lncRNA(s)/alias Stage of B-cell Genome location Function Molecular mechanism Reference(s)
MYB-AS1, SMAD1-AS1, LEF1-AS1 pre-B1 and pre-B2 cells 6q23.3, 4q31.21, 4q25 Involvement in early B-cell development Antisense transcripts to TFs with well-known roles in early B-cells [23]
CRNDE pre-B1, pre-B2, CBs and, to a lesser extent, CCs 16q12.2 Involvement in mitotic cell cycle related processes Promotion of the metabolic changes by which cancer cells switch to aerobic glycolysis [23, 2527]
RP11-132N15.3/lnc-BCL6-3 CBs and, to a lesser extent, CCs 3q27.3 Involvement in the modulation of the GC reaction LincRNA possibly regulating the transcriptional repressor BCL-6 [23]

Abbreviations: CC, centrocyte; CB, centroblast; GC, germinal center