Table 1.
Summary of ACB‐PCR MF Measurements
| Sample type | Gene mutation | Tissue | Median MF | Geomean MF | No. samples >10−5 | No. samples <10−5 | Mutation positive samples (%) |
|---|---|---|---|---|---|---|---|
| Normal | PIK3CA H1047R | Colon | 1.57 × 10−5 | 1.98 × 10−5 | 20 | 0 | 100 |
| PIK3CA H1047R | Lung | 2.45 × 10−5 | 3.96 × 10−5 | 19 | 0 | 100 | |
| PIK3CA E545K | Breast | 6.06 × 10−6 | 1.78 × 10−5 | 4 | 6 | 40 | |
| PIK3CA E545K | Colon | 2.67 × 10−6 | 2.69 × 10−6 | 0 | 20 | 0 | |
| PIK3CA E545K | Lung | 5.35 × 10−6 | 6.75 × 10−6 | 3 | 16 | 16 | |
| PIK3CA E545K | Thyroid | 6.52 × 10−6 | 7.02 × 10−6 | 5 | 14 | 26 | |
| KRAS G12D | Colon | 2.88 × 10−5 | 4.90 × 10−5 | 15 | 0 | 100 | |
| KRAS G12V | Colon | 7.66 × 10−6 | 1.08 × 10−5 | 6 | 9 | 40 | |
| Adenoma | PIK3CA H1047R | Colon | 1.73 × 10−5 | 4.56 × 10−5 | 8 | 1 | 89 |
| PIK3CA E545K | Colon | 2.15 × 10−6 | 2.38 × 10−6 | 2 | 6 | 25 | |
| Carcinoma | PIK3CA H1047R | Colon | 1.63 × 10−5 | 3.46 × 10−5 | 19 | 1 | 95 |
| PIK3CA H1047R | Lung | 2.54 × 10−5 | 3.48 × 10−5 | 24 | 0 | 100 | |
| PIK3CA E545K | Breast | 3.92 × 10−5 | 8.36 × 10−5 | 7 | 2 | 78 | |
| PIK3CA E545K | Colon | 3.07 × 10−6 | 7.89 × 10−6 | 3 | 17 | 15 | |
| PIK3CA E545K | Lung | 4.17 × 10−6 | 7.13 × 10−6 | 4 | 20 | 8 | |
| PIK3CA E545K | Thyroid | 8.39 × 10−6 | 8.78 × 10−6 | 7 | 11 | 39 |
The median and geomean MFs shown in italics are below the limit of accurate ACB‐PCR quantification (10−5).