TABLE 3.
Antibiotics used in this studyc
| Antibiotic | Class | Log10 CFUa |
Mass (g/mol) | Log Pb | |||
|---|---|---|---|---|---|---|---|
| Maltodextrin |
PEG 400 |
||||||
| Untreated | Treated | Untreated | Treated | ||||
| Tobramycin | Aminoglycoside | 8.14 ± 0.18 | 2.56 ± 0.14 | 7.53 ± 0.13 | 1.15 ± 0.26 | 565 | −6.2 |
| Gentamicin | Aminoglycoside | 8.07 ± 0.12 | 1.4 ± 0.15 | 8.31 ± 0.16 | 1.5 ± 0.04 | 477 | −4.1 |
| Kanamycin | Aminoglycoside | 8.17 ± 0.12 | 1.25 ± 0.34 | 8.21 ± 0.13 | 1.1 ± 0.24 | 582 | −6.9 |
| Ciprofloxacin | Fluoroquinolone | 8.27 ± 0.16 | 2.73 ± 0.16 | 7.24 ± 0.2 | 1.14 ± 0.05 | 331 | −1.1 |
| Chloramphenicol | Amphenicol | 7.8 ± 0.09 | 3.04 ± 0.19 | 7.5 ± 0.03 | 2.34 ± 0.18 | 323 | 1.1 |
| Ceftiofur | Cephalosporin | 7.92 ± 0.16 | 4.2 ± 0.05 | 7.89 ± 0.08 | 3.35 ± 0.26 | 523 | 0.2 |
| Nalidixic acid | Quinolone | 8.27 ± 0.19 | 4.75 ± 0.01 | 7.65 ± 0.01 | 3.62 ± 0.03 | 232 | 1.4 |
| Streptomycin | Aminoglycoside | 8.22 ± 0.2 | 5.46 ± 0.03 | 7.96 ± 0.03 | 4.51 ± 0.23 | 1,457 | −8 |
| Erythromycin | Macrolide | 8.21 ± 0.16 | 7.18 ± 0.14 | 8.18 ± 0.19 | 5.3 ± 0.13 | 733 | 2.7 |
| Ampicillin | Beta-lactam | ND | ND | 7.79 ± 0.15 | 4.44 ± 0.17 | 371 | −1.1 |
| Trimethoprim | Miscellaneous | ND | ND | 7.61 ± 0.16 | 4.11 ± 0.32 | 290 | 0.9 |
a
Log10 CFU expresses the log10-transformed average number of cells recovered (± standard error of the mean) from untreated biofilms and number of cells recovered from biofilms that were treated with antibiotic and maltodextrin (20 mM) or PEG 400 (26.6 mM).
b
Log P is the partial coefficient between n-octanol and water. A high log P value indicates greater lipophilicity, whereas a low value indicates greater hydrophilicity.
c
Log P and mass values were obtained from PubChem Compound (https://www.ncbi.nlm.nih.gov/pccompound/). ND, not determined.