FIG 3.

Unrooted neighbor-joining tree of the d-isomer-specific 2-hydroxyacid dehydrogenase superfamily (PROSITE entry PDOC00063_pattern_1). The evolutionary history was inferred using the neighbor-joining method. The analysis involved 185 amino acid sequences. All positions containing gaps and missing data were eliminated. Sequences clustering together and representing separate enzymatic subgroups are shaded. d-LDH, d-lactate dehydrogenases; SERA, d-3-phosphoglycerate dehydrogenases; PDXB, erythronate-4-phosphate dehydrogenases; FDH, formate dehydrogenases; GHPR, glyoxylate/hydroxypyruvate reductases; CTBP, C-terminal binding proteins. B. multivorans LdhA is in red font.