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. 2017 Sep 15;83(19):e01323-17. doi: 10.1128/AEM.01323-17

FIG 4.

FIG 4

Treatment with gliadin and srp-expressing B. longum shifts fecal microbiota profiles. The figure presents principal-coordinate analysis plots of 16S data in NOD/DQ8 mice. (A) Gliadin induces a shift in β-diversity as calculated using the Unifrac unweighted distance method (P < 0.001). Microbial compositions were different between mice receiving B. longum Δsrp and those receiving B. longum srp+ (P < 0.05); those receiving B. longum Δsrp and those receiving B. longum srp(Con) (P < 0.001); and those receiving B. longum srp+ and those receiving B. longum srp(Con) (P < 0.001) (n = 5 to 6/group). (B) Gliadin also shifted β-diversity as assessed using Bray-Curtis dissimilarity parameters (P < 0.005). Microbial compositions are significantly different between B. longum Δsrp and B. longum srp+ (P < 0.05); between B. longum Δsrp and B. longum srp(Con) (P < 0.005); and between B. longum srp+ and B. longum srp(Con) (P < 0.005). Each circle represents an individual fecal sample (n = 5 to 6/group). Control, nonsensitized, no treatment; srp+, B. longum srp+; Δsrp, B. longum Δsrp; srp(Con), B. longum srp(Con). Statistical analyses were performed via PERMANOVA in QIIME. Plots were constructed in R.