Figure 2.

Correlations between the negative logarithm of the human adenosine A₃ receptor antagonists’ dissociation rates (pk_off) and their kinetic rate index (KRI) (A), the human adenosine A₃ receptor antagonists’ affinity (pK_i) and their “kinetic K_D” (pK_D) (B), association rate constants (log k_on) (C), and dissociation rate constants (pk_off) (D). The central line corresponds to the linear regression of the data, the dotted lines represent the 95% confidence intervals for the regression. Data used in these plots are detailed in Tables 1–3. Data are expressed as mean from at least three independent experiments.