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Structures of mGlu3 NAM 3 and the optimized mGlu3 NAM 4 via a reductionist approach to the minimum pharmacophore possessing the desired potency, selectivity, and CNS penetration. A similar strategy for 2 will ideally afford a simplified picolinamide-based mGlu2 NAM 5 with the desired potency, selectivity, and CNS penetration.21
