Table 1. Inhibition of hCA Isoforms I, II, IX and XII with Compounds 1a–d and 2a–d.

	Ki (μM)a
compd	hCA Ib	hCA IIb	hCA IXc	hCA XIIc
1a	0.042 ± 0.0001	1820 ± 9	7.79 ± 0.06	7.78 ± 0.04
1b	5.33 ± 0.04	4.70 ± 0.01	4.51 ± 0.03	0.34 ± 0.006
1c	4.83 ± 0.07	0.70 ± 0.008	18.9 ± 0.21	0.28 ± 0.01
1d	6.61 ± 0.02	0.78 ± 0.009	2.91 ± 0.04	0.44 ± 0.005
2a	4.31 ± 0.06	6.95 ± 0.08	0.47 ± 0.003	0.57 ± 0.008
2b	5.93 ± 0.06	0.53 ± 0.003	7.90 ± 0.08	0.35 ± 0.002
2c	6.45 ± 0.03	0.76 ± 0.05	7.36 ± 0.04	0.21 ± 0.01
2d	0.62 ± 0.005	0.41 ± 0.007	3.02 ± 0.008	0.31 ± 0.01
AAZ	0.25 ± 0.01	0.012 ± 0.001	0.025 ± 0.002	0.006 ± 0.0005
MZA	0.78 ± 0.04	0.014 ± 0.001	0.027 ± 0.008	0.034 ± 0.002
DCP	1.2 ± 0.1	0.038 ± 0.003	0.050 ± 0.005	0.050 ± 0.004

^aErrors in the range of ±5–10% of the reported value from three different determinations.

^bFull length.

^cCatalytic domain. AAZ, acetazolamide; MZA, methazolamide; DCP, dichlorophenamide.