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. 2017 Sep 15;7:11696. doi: 10.1038/s41598-017-12064-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Endothelium in wild-type and Col4a3 mutant mice. (a) HIM images of glomerular filtration slits in wild-type (WT), Col4a3+/−, and Col4a3−/− mice. The image of WT endothelium shows a smooth endothelial surface and endothelial fenestrae of regular size. Underlying the endothelial fenestrae, a diaphragm like structure is detectable (*). The image of Col4a3+/− endothelium shows a similar pattern to WT. The Col4a3−/− endothelium shows irregular sizes of endothelial fenestrae and disappearance of the diaphragm-like structure underneath the fenestrae (white arrows). Scale bars, 100 nm. (b) The diameter of endothelial fenestrae is significantly decreased in Col4a3−/− (n = 46) mice but not in Col4a3+/− (n = 41) mice compared to WT (n = 43) (**p < 0.01 by Student’s t-test).