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| biological assay/test procedure | compound 1 |
|---|---|
| hCCR4 binding (pIC50) | 7.2 ± 0.2 |
| hPPB (%) | >99.9 |
| calcd WBP (pIC50)a | <4.2 |
| logD | 1.1 |
| solubility (mg/mL) | 0.34 |
| human hepatocytes (μL/mL/106 cells) | <0.2 |
| rat/mouse in vivo PK | |
| Cl (mL/min/kg) | 0.1/0.1 |
| Vss (L/kg) | 0.1/0.1 |
| T1/2 (h) | 16/10 |
| bioavailability (%) | 45/86 |
| rat/mouse CCR4 binding (pIC50) | 8.3/8.3 |
| rat/mouse PPB (%) | 99.85/96.7 |
Calculated from the hCCR4 binding and % age PPB.
