Table 6. Potency of 47 and 49 for Inhibition of Cellular Responses Mediated by the Human CCR4 Receptor.

cell system	assay readout	47 (pIC50 mean ± SEM)	49 (pIC50 mean ± SEM)
inhibition of CCL22 Ca2+ response	MDC-induced Ca2+ flux	7.5 ± 0.04 (n = 3) (CHO cells expressing hCCR4)	8.4 ± 0.1 (n = 4) (HEK cells expressing hCCR4)
inhibition of Th2 cell CCL22 driven chemotaxis in 0.3% HSA	MDC-induced chemotaxis	6.3 ± 0.2 (n = 3)	6.8 ± 0.2 (n = 3)
inhibition of Th2 cell CCL17 driven chemotaxis in 0.3% HSA	TARC-induced chemotaxis	6.3 ± 0.1 (n = 3)	6.5 (n = 1)