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. 2017 Sep 15;7:11723. doi: 10.1038/s41598-017-10639-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Immunohistology for a chronically implanted VN. Fluorescent images shown at 10x magnification. (a) Cleared VN with implanted CNT yarn electrodes. Nerve shown after 21 days of passive clearing. (b) Fluorescent stain for major histocompatibility complex class II (MHC-II, ab55152), present on antigen-presenting immune cells (e.g. activated microglia). (c) Fluorescent stain for oligodendrocyte specific protein (OSP, ab7474). (d) Fluorescent stain for DNA (DAPI). DAPI is used to stain cell nucleii. Arrows show elevated DAPI density around the wires, used to estimate thickness of fibrous encapsulation. (e) Composite image showing MHC-II, OSP, and DAPI stains.