Table 1.
Mean, standard deviation (SD) and median volume of dominant intraprostatic tumour lesion on each multiparametric MRI sequence for all patients (Cohorts 1 and 2, n = 40) and for Cohort 1 alone (n = 20). Volume data derived from prostatectomy samples in Cohort 1 is shown for comparison
| Sequence | Statistical parameter | Observer 1 | Observer 2 | Histology |
|---|---|---|---|---|
| T2W | Mean ± SD (cm3) (All) |
2.40 ± 1.93 | 2.29 ± 1.93 | |
| Median (cm3) (All) |
1.77 | 1.60 | ||
| Mean ± SD (cm3) (Cohort 1) |
1.84 ± 1.85 | 1.54 ± 1.60 | 1.46 ± 1.5 | |
| Median (cm3) (Cohort 1) |
1.1 | 1.01 | 0.71 | |
| DW-MRI | Mean ± SD (cm3) (All) |
1.77 ± 1.58 | 1.62 ± 1.43 | |
| Median (cm3) (All) |
1.17 | 1.19 | ||
| Mean ± SD (cm3) (Cohort 1) |
1.46 ± 1.70 | 1.13 ± 1.35 | ||
| Median (cm3) (Cohort 1) |
0.79 | 0.61 | ||
| DCE-MRI | Mean ± SD (cm3) (All) |
1.01 ± 0.99 | 0.9 ± 1.1 | |
| Median (cm3) (All) |
0.82 | 0.71 | ||
| Mean ± SD (cm3) (Cohort 1) |
0.68 ± 0.98 | 0.48 ± 0.88 | ||
| Median (cm3) (Cohort 1) |
0.33 | 0.15 | ||
| Average of all sequences combined | Mean ± SD (cm3) (All) |
1.73 ± 1.44 | 1.62 ± 1.43 | |
| Median (cm3) (All) |
1.27 | 1.16 | ||
| Mean ± SD (cm3) (Cohort 1) |
1.33 ± 1.46 | 1.05 ± 1.23 | ||
| Median (cm3) (Cohort 1) |
0.71 | 0.56 |
T2W, T2 weighted; DCE, dynamic contrast-enhanced; DW, diffusion-weighted.