Figure 1. Effects of kinase inhibition on the proliferation of leukemia cells.
A. Human leukemia cell lines were treated with duplicate serial dilutions of kinase inhibitors and the effect on cell viability was determined by Cell Titer Glo assay after 48 hours. Data shown represents the mean IC50 of each condition from 2 independent experiments. HL-60 cells were treated with serial dilutions of mTor/PI3K B. and MEK C. inhibitors and the effect on cell viability was determined after 48 hours. Data shown is the mean ± SEM of 3 independent experiments. Note, in some instances error bars are smaller than symbols displayed.