Table 3. Summary of drugs effects on cell proliferation and protein expression in vitro.

	CRMM1	CRMM2	CM2005.1
Mutations a
BRAF V600E	+	-	+
NRAS Q61L	-	+	-
Inhibitiont of cell proliferation b
BRAFi
Vemurafenib	+	-	+
Dabrafenib	+	-	+
MEKi
MEK162	+	+	+
AKTi
MK2206	+	+	+
Drug effect on phosphorylated protein expression c
Vemurafenib	p-ERK↓	p-ERK↑	p-ERK↓
Dabrafenib	p-ERK↓	p-ERK↑	p-ERK↓
MEK162	p-ERK↓	p-ERK↓	p-ERK↓
MK2206	p-AKT↓	p-AKT↓	p-AKT↓

^a “+” means mutant, and “-” indicates wild type.

^b “+” shows cell proliferation was inhibited, while “-” demonstrates cell viability was not influenced.

^c “↑” represents phosphorylation of proteins was increased, while “↓” implies phosphorylation of proteins was decreased.