Table 2. Evaluation of associations between detected HABP2 genotypes (GG, GA, and AA) and clinical variables.
| Characteristic | Genotype | Statistical significance | |||
|---|---|---|---|---|---|
| GG | AA | GA | |||
| Gender | F/M | 286/28 | 1/0 | 10/1 | NS |
| Median tumor diameter (mm) | 8 | 25 | 13 | NS | |
| Age (years) | 50 | 62 | 37 | NS | |
| Tumor stage | T1 | 228 | 0 | 7 | NS |
| T2 | 19 | 0 | 1 | ||
| T3 | 54 | 1 | 3 | ||
| T4 | 13 | 0 | 0 | ||
| Lymph node involvement | N0 | 123 | 1 | 5 | NS |
| N1 | 28 | 0 | 0 | ||
| Nx | 163 | 0 | 6 | ||
| Metastasis | M0 | 313 | 1 | 11 | NS |
| M1 | 1 | 0 | 0 | ||
| Extra-thyroidal invasion | Yes | 63 | 0 | 2 | NS |
| No | 251 | 1 | 9 | ||
| Multifocality | Yes | 261 | 1 | 8 | NS |
| No | 53 | 0 | 3 | ||
| PTC type | Classical | 276 | 1 | 7 | NS |
| Follicular | 35 | 0 | 4 | ||
| Oxyphilic | 3 | 0 | 0 | ||
| Response to therapy | Excellent | 280 | 1 | 10 | NS |
| Indeterminate | 14 | 0 | 1 | ||
| Biochemically incomplete | 3 | 0 | 0 | ||
| Structurally incomplete | 17 | 0 | 0 | ||
| Follow-up (years) | Median (Min–Max) | 7 (1–48) | 6 (6–6) | 5 (3–15) | NS |
| Status of final follow-up | No evidence of disease | 295 | 1 | 10 | NS |
| Biochemically persistent disease | 17 | 0 | 1 | ||
| Persistent structural disease | 1 | 0 | 0 | ||
| Recurrence | 1 | 0 | 0 | ||
| Death | 0 | 0 | 0 | ||
| Total | 314 | 1 | 11 | ||
Associations between genotypes and clinical variables were assessed using χ2 and Kruskal-Wallis tests. NS, not statistically significant; F, female; M, male.