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. 2017 Apr 6;8(35):58338–58352. doi: 10.18632/oncotarget.16873

Figure 1. TNF-α administration is able to promote the proliferation of breast cancer cells through activating TNFR1.

Figure 1

(A, B) Effect of TNF-α on cell proliferation was measured by MTT assays in MDA-MB-468 and SK-BR3 which were added into 20 ng/ml TNF-α and transiently transfected with si-TNFR1, respectively. (C) Effect of TNF-α on cell proliferation was determined by EdU assays in MDA-MB-468 cells added into 20 ng/ml TNF-α and transiently transfected with si-TNFR1. (D) Effect of TNF-α and si-TNFR1 on the clonogenicity of MDA-MB-468 and SK-BR3 cells was examined by monolayer colony formation assays. Error bars represent ±s.d., *p < 0.05, **p < 0.01, Student's t test. All experiments were repeated at least 3 times.